Spurs slipped to a third consecutive defeat in all competitions after two red cards at Bournemouth.
Tottenham have put themselves in a difficult position in the race for Premier League top-four after a 1-0 loss to Bournemouth on Saturday.
Third-placed Spurs would have secured Champions League qualification for next season with a win, but they were brilliantly restricted on several occasions by the 19-year-old debutant Mark Travers in Bournemouth’s goal before losing their cool.
Heung-min Son was sent off just before the interval and his replacement Juan Foyth followed suit three minutes after the break.
And after defending Bournemouth for the majority of the second half, Mauricio Pochettino’s men allowed Nathan Ake to nod in the winner in stoppage time.
Spurs will now need victory against Everton after their trip to Ajax as their Champions League involvement both this season and next hangs in the balance.
Travers made a series of brilliant saves, turning away a powerful drive and a header from Dele Alli, and twice denied Lucas Moura as he exploited space behind a disorganised Bournemouth defence.
But a one-sided contest took a turn just two minutes before half-tome as Son saw red.
Referee Craig Pawson had been lenient enough, having turned down two penalty appeals from Bournemouth and opting against showing Eric Dier a second yellow card, but Son was given his marching orders after he shoved Jefferson Lerma to the ground.
Foyth and Victor Wanyama were introduced at the interval as Pochettino took no risks with Dier and Toby Alderweirld, also warned, yet the incoming defender soon pounced in on Jack Simpson and Tottenham were reduced to nine men.
The hosts appeared as though they would be frustrated by a resolute Spurs defence, but Ake broke the deadlock in injury with a header from Ryan Fraser’s corner, landing another blow to the visitors.
It means Spurs are place in next season’s Champions League is far from guaranteed and they will need results in their next two games in all competitions if they are to qualify.
What the managers said
Bournemouth boss Eddie Howe:
“I think (survival) is a huge achievement. At the end of the season our biggest challenge is always to keep our best players. We’ve been able to do that to this point, I think this will be our biggest summer in terms of doing that. I am confident that we can and it’s really important that we do.”
Tottenham boss Mauricio Pochettino:
“Two red cards, very difficult for the team – we fight, we made the effort, only disappointed and we need to move on. I respect the decision of the referee. We are third, we are competing for the top four, we are in the semi-final of the Champions League – I think if you go back to our first game of the season in the Premier League, everybody would sign to be in the position that we are in.
Tottenham fly to Amsterdam looking to overturn a 1-0 deficit to Ajax before facing Everton in their last Premier League match. Bournemouth finish their season at Crystal Palace.